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Catalytic vs. Inhibitory Promiscuity in Cytochrome P450s: Implications for Evolution of New Function

Catalytically promiscuous enzymes are intermediates in the evolution of new function from an existing pool of protein scaffolds. However, promiscuity will only confer an evolutionary advantage if other useful properties are not compromised, or if there is no ‘negative trade-off’ induced by the mutat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Foti, Robert S., Honaker, Mathew, Nath, Abhinav, Pearson, Josh T., Buttrick, Brian, Isoherranen, Nina, Atkins, William M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068220/
https://ncbi.nlm.nih.gov/pubmed/21370922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1020716
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