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Catalytic vs. Inhibitory Promiscuity in Cytochrome P450s: Implications for Evolution of New Function
Catalytically promiscuous enzymes are intermediates in the evolution of new function from an existing pool of protein scaffolds. However, promiscuity will only confer an evolutionary advantage if other useful properties are not compromised, or if there is no ‘negative trade-off’ induced by the mutat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3068220/ https://ncbi.nlm.nih.gov/pubmed/21370922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1020716 |
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