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Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray–derived conformational ensembles
How enzymes achieve their enormous rate enhancements remains a central question in biology, and our understanding to date has impacted drug development, influenced enzyme design, and deepened our appreciation of evolutionary processes. While enzymes position catalytic and reactant groups in active s...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7776779/ https://ncbi.nlm.nih.gov/pubmed/33376217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011350117 |
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