Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray–derived conformational ensembles

How enzymes achieve their enormous rate enhancements remains a central question in biology, and our understanding to date has impacted drug development, influenced enzyme design, and deepened our appreciation of evolutionary processes. While enzymes position catalytic and reactant groups in active s...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Yabukarski, Filip, Biel, Justin T., Pinney, Margaux M., Doukov, Tzanko, Powers, Alexander S., Fraser, James S., Herschlag, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776779/
https://ncbi.nlm.nih.gov/pubmed/33376217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011350117
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