Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes

Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the reduced autophagy contributes to the pathogenesis of diabetic cardiomyopathy. We addressed this question using mouse models with gain- and loss-of-autophagy. Autophagic flux was inhibited in diabetic hearts when me...

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Detaylı Bibliyografya
Asıl Yazarlar: Xu, Xianmin, Kobayashi, Satoru, Chen, Kai, Timm, Derek, Volden, Paul, Huang, Yuan, Gulick, James, Yue, Zhenyu, Robbins, Jeffrey, Epstein, Paul N., Liang, Qiangrong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689952/
https://ncbi.nlm.nih.gov/pubmed/23658055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474650
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