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Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms

Caloric restriction (CR) is a dietary intervention known to enhance cardiovascular health. The glucose analog 2-deoxy-d-glucose (2-DG) mimics CR effects in several animal models. However, whether 2-DG is beneficial to the heart remains obscure. Here, we tested the ability of 2-DG to reduce cardiomyo...

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Hlavní autoři: Chen, Kai, Xu, Xianmin, Kobayashi, Satoru, Timm, Derek, Jepperson, Tyler, Liang, Qiangrong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121344/
https://ncbi.nlm.nih.gov/pubmed/21521688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.225805
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