Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated Autophagy

Resveratrol is a plant-derived polyphenol that can attenuate the cardiotoxic effects of doxorubicin (DOX), a powerful antibiotic widely used in cancer chemotherapy. However, the underlying protective mechanisms of resveratrol remain elusive. Here, we show that resveratrol inhibited DOX-induced autop...

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Bibliographic Details
Main Authors: Xu, Xianmin, Chen, Kai, Kobayashi, Satoru, Timm, Derek, Liang, Qiangrong
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310694/
https://ncbi.nlm.nih.gov/pubmed/22209892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189589
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