UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

Pretreatment of 3T6 murine cells with the carcinogen UV radiation or N-acetoxy-N-acetylaminofluorene increased the number of methotrexate-resistant colonies. This carcinogen-induced enhancement was seen only at low toxicities. The enhancement was transient and was observed at its maximum when cells...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Tlsty, T D, Brown, P C, Schimke, R T
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1984
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368872/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6738530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.4.6.1050-1056.1984
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