Loading...

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA sequences coding for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). In some cell variants the amplif...

Full description

Saved in:
Bibliographic Details
Main Authors: Kaufman, R J, Brown, P C, Schimke, R T
Format: Artigo
Language:Inglês
Published: 1979
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC411711/
https://ncbi.nlm.nih.gov/pubmed/293670
Tags: Add Tag
No Tags, Be the first to tag this record!