Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA sequences coding for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). In some cell variants the amplif...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Kaufman, R J, Brown, P C, Schimke, R T
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1979
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/293670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.11.5669
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