UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

Pretreatment of 3T6 murine cells with the carcinogen UV radiation or N-acetoxy-N-acetylaminofluorene increased the number of methotrexate-resistant colonies. This carcinogen-induced enhancement was seen only at low toxicities. The enhancement was transient and was observed at its maximum when cells...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Tlsty, T D, Brown, P C, Schimke, R T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1984
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368872/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6738530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.4.6.1050-1056.1984
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