Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Hedgehog signalling—an essential pathway during embryonic pancreatic development, the misregulation of which has been implicated in several forms of cancer—may also be an important mediator in human pancreatic carcinoma(1–8). Here we report that sonic hedgehog, a secreted hedgehog ligand, is abnorma...

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Hauptverfasser: Thayer, Sarah P., Pasca di Magliano, Marina, Heiser, Patrick W., Nielsen, Corinne M., Roberts, Drucilla J., Lauwers, Gregory Y., Ping Qi, Yan, Gysin, Stephan, Fernández-del Castillo, Carlos, Yajnik, Vijay, Antoniu, Bozena, McMahon, Martin, Warshaw, Andrew L., Hebrok, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688051/
https://ncbi.nlm.nih.gov/pubmed/14520413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature02009
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