Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis

Activation of sonic hedgehog (Shh) signaling occurs in the majority of pancreatic ductal adenocarcinomas. Here we investigate the mechanisms by which Shh contributes to pancreatic tumorigenesis. We find that Shh expression enhances proliferation of pancreatic duct epithelial cells, potentially throu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Morton, Jennifer P., Mongeau, Michelle E., Klimstra, David S., Morris, John P., Lee, Yie Chia, Kawaguchi, Yoshiya, Wright, Christopher V. E., Hebrok, Matthias, Lewis, Brian C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828712/
https://ncbi.nlm.nih.gov/pubmed/17372229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701158104
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