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Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
Activation of sonic hedgehog (Shh) signaling occurs in the majority of pancreatic ductal adenocarcinomas. Here we investigate the mechanisms by which Shh contributes to pancreatic tumorigenesis. We find that Shh expression enhances proliferation of pancreatic duct epithelial cells, potentially throu...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1828712/ https://ncbi.nlm.nih.gov/pubmed/17372229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701158104 |
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