ATM kinase inhibition preferentially sensitizes p53 mutant glioma to ionizing radiation

PURPOSE: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a median survival of only 12–15 months. Current standard treatment consists of surgery followed by chemoradiation. The poor survival of GBM patients is due to aggressive tumor invasiveness, an inability to remove all...

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Autori principali: Biddlestone-Thorpe, Laura, Sajjad, Muhammad, Rosenberg, Elizabeth, Beckta, Jason M., Valerie, Nicholas C.K., Tokarz, Mary, Adams, Bret R., Wagner, Alison F., Khalil, Ashraf, Gilfor, Donna, Golding, Sarah E., Deb, Sumitra, Temesi, David G., Lau, Alan, O'Connor, Mark J., Choe, Kevin S., Parada, Luis F., Lim, Sang Kyun, Mukhopadhyay, Nitai D., Valerie, Kristoffer
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687028/
https://ncbi.nlm.nih.gov/pubmed/23620409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3408
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