ATM kinase inhibition preferentially sensitizes p53 mutant glioma to ionizing radiation

PURPOSE: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a median survival of only 12–15 months. Current standard treatment consists of surgery followed by chemoradiation. The poor survival of GBM patients is due to aggressive tumor invasiveness, an inability to remove all...

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書誌詳細
主要な著者: Biddlestone-Thorpe, Laura, Sajjad, Muhammad, Rosenberg, Elizabeth, Beckta, Jason M., Valerie, Nicholas C.K., Tokarz, Mary, Adams, Bret R., Wagner, Alison F., Khalil, Ashraf, Gilfor, Donna, Golding, Sarah E., Deb, Sumitra, Temesi, David G., Lau, Alan, O'Connor, Mark J., Choe, Kevin S., Parada, Luis F., Lim, Sang Kyun, Mukhopadhyay, Nitai D., Valerie, Kristoffer
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687028/
https://ncbi.nlm.nih.gov/pubmed/23620409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3408
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