ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status

Replication stress and DNA damage activate the ATR-CHK1 checkpoint signaling pathway that licenses repair and cell survival processes. In this study, we examined the respective roles of the ATR and CHK1 kinases in ovarian cancer cells using genetic and pharmacological inhibitors of in combination wi...

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Autores principales: Huntoon, Catherine J., Flatten, Karen S., Wahner Hendrickson, Andrea E., Huehls, Amelia M., Sutor, Shari L., Kaufmann, Scott H., Karnitz, Larry M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687010/
https://ncbi.nlm.nih.gov/pubmed/23548269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0110
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