Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors

Mutations in the tumor suppressors BRCA1 and BRCA2, which encode proteins that are key participants in homologous recombination (HR) repair, occur in ∼20% of high grade serous ovarian cancers. Although only 20% of these tumors have mutations in BRCA1 and BRCA2, nearly 50% of these tumors have defect...

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Bibliografiske detaljer
Main Authors: Joshi, Poorval M., Sutor, Shari L., Huntoon, Catherine J., Karnitz, Larry M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979363/
https://ncbi.nlm.nih.gov/pubmed/24554720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551143
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