ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status

Replication stress and DNA damage activate the ATR-CHK1 checkpoint signaling pathway that licenses repair and cell survival processes. In this study, we examined the respective roles of the ATR and CHK1 kinases in ovarian cancer cells using genetic and pharmacological inhibitors of in combination wi...

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Detalhes bibliográficos
Main Authors: Huntoon, Catherine J., Flatten, Karen S., Wahner Hendrickson, Andrea E., Huehls, Amelia M., Sutor, Shari L., Kaufmann, Scott H., Karnitz, Larry M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687010/
https://ncbi.nlm.nih.gov/pubmed/23548269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0110
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