BRCA1 Deficiency Upregulates NNMT Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

BRCA1 plays a key role in homologous recombination (HR) DNA repair. Accordingly, changes that downregulate BRCA1, including BRCA1 mutations and reduced BRCA1 transcription, due to promoter hypermethylation or loss of the BRCA1 transcriptional regulator CDK12, disrupt HR in multiple cancers. In addit...

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Publicado no:Cancer Res
Main Authors: Kanakkanthara, Arun, Kurmi, Kiran, Ekstrom, Thomas L., Hou, Xiaonan, Purfeerst, Emma R., Heinzen, Ethan P., Correia, Cristina, Huntoon, Catherine J., O’Brien, Daniel, Hendrickson, Andrea E. Wahner, Dowdy, Sean C., Li, Hu, Oberg, Ann L., Hitosugi, Taro, Kaufmann, Scott H., Weroha, S. John, Karnitz, Larry M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891213/
https://ncbi.nlm.nih.gov/pubmed/31619387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1405
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