Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

We investigated various parameters associated with the initial selection of mouse 3T6 cells for resistance to single concentrations of methotrexate and characterized resistant colonies for the presence of additional (amplified) copies of the dihydrofolate reductase gene. Our results indicate that th...

Ful tanımlama

Detaylı Bibliyografya

Yayımlandı:	Mol Cell Biol
Asıl Yazarlar:	Brown, P C, Tlsty, T D, Schimke, R T
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Taylor & Francis 1983
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6877240/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.3.6.1097-1107.1983
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!