Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

We investigated various parameters associated with the initial selection of mouse 3T6 cells for resistance to single concentrations of methotrexate and characterized resistant colonies for the presence of additional (amplified) copies of the dihydrofolate reductase gene. Our results indicate that th...

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Publicado en:	Mol Cell Biol
Autores principales:	Brown, P C, Tlsty, T D, Schimke, R T
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1983
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6877240/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.3.6.1097-1107.1983
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