In Vitro Study of α-Synuclein Protofibrils by Cryo-EM Suggests a Cu(2+)-Dependent Aggregation Pathway

The aggregation of α-synuclein is thought to play a role in the death of dopamine neurons in Parkinson’s disease (PD). Alpha-synuclein transitions itself through an aggregation pathway consisting of pathogenic species referred to as protofibrils (or oligomer), which ultimately convert to mature fibr...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Hangyu, Griggs, Amy, Rochet, Jean-Christophe, Stanciu, Lia A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2013
Ämnen:
Proteins and Nucleic Acids
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686339/
https://ncbi.nlm.nih.gov/pubmed/23790379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.050
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk