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In Vitro Study of α-Synuclein Protofibrils by Cryo-EM Suggests a Cu(2+)-Dependent Aggregation Pathway
The aggregation of α-synuclein is thought to play a role in the death of dopamine neurons in Parkinson’s disease (PD). Alpha-synuclein transitions itself through an aggregation pathway consisting of pathogenic species referred to as protofibrils (or oligomer), which ultimately convert to mature fibr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3686339/ https://ncbi.nlm.nih.gov/pubmed/23790379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.050 |
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