In Vitro Study of α-Synuclein Protofibrils by Cryo-EM Suggests a Cu(2+)-Dependent Aggregation Pathway

The aggregation of α-synuclein is thought to play a role in the death of dopamine neurons in Parkinson’s disease (PD). Alpha-synuclein transitions itself through an aggregation pathway consisting of pathogenic species referred to as protofibrils (or oligomer), which ultimately convert to mature fibr...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Hangyu, Griggs, Amy, Rochet, Jean-Christophe, Stanciu, Lia A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2013
Onderwerpen:
Proteins and Nucleic Acids
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686339/
https://ncbi.nlm.nih.gov/pubmed/23790379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.050
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