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Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase
[Image: see text] Mutations in isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, have recently been found in ∼75% glioma and ∼20% acute myeloid leukemia. Different from the wild-type enzyme, mutant IDH1 catalyzes the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical Society
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3686309/ https://ncbi.nlm.nih.gov/pubmed/23795241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400036z |
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