Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase

[Image: see text] Mutations in isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, have recently been found in ∼75% glioma and ∼20% acute myeloid leukemia. Different from the wild-type enzyme, mutant IDH1 catalyzes the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Baisong, Yao, Yuan, Liu, Zhen, Deng, Lisheng, Anglin, Justin L., Jiang, Hong, Prasad, B. V. Venkataram, Song, Yongcheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2013
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686309/
https://ncbi.nlm.nih.gov/pubmed/23795241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400036z
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