Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity

[Image: see text] Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant enzymes catalyze the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric acid (D2HG), leading to cancer initiation. Several...

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Autors principals: Liu, Zhen, Yao, Yuan, Kogiso, Mari, Zheng, Baisong, Deng, Lisheng, Qiu, Jihui J., Dong, Shuo, Lv, Hua, Gallo, James M., Li, Xiao-Nan, Song, Yongcheng
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207540/
https://ncbi.nlm.nih.gov/pubmed/25271760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500660f
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