Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase

[Image: see text] 1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the nonmevalonate isoprene biosynthesis pathway is a target for developing antimalarial drugs. Fosmidomycin, a potent DXR inhibitor, showed safety as well as efficacy against Plasmodium falciparum malaria in clinical trials....

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Bibliographic Details
Main Authors: Xue, Jian, Diao, Jiasheng, Cai, Guobin, Deng, Lisheng, Zheng, Baisong, Yao, Yuan, Song, Yongcheng
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685428/
https://ncbi.nlm.nih.gov/pubmed/23795240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300419r
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