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Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase
[Image: see text] 1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the nonmevalonate isoprene biosynthesis pathway is a target for developing antimalarial drugs. Fosmidomycin, a potent DXR inhibitor, showed safety as well as efficacy against Plasmodium falciparum malaria in clinical trials....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American
Chemical Society
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685428/ https://ncbi.nlm.nih.gov/pubmed/23795240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300419r |
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