Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. T...

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Bibliografiske detaljer
Main Authors: Mishra, Aseem, Misra, Anurag, Sri Vaishnavi, T., Thota, Chaitanya, Gupta, Madhvi, Ramakumar, Suryanarayanarao, Chauhan, Virander Singh
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2013
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684849/
https://ncbi.nlm.nih.gov/pubmed/23435449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc38982k
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