Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus

Human islet amyloid polypeptide (hIAPP), a pancreatic islet protein of 37 amino acids, is the main component of islet amyloid, seen at autopsy in patients with type 2 diabetes mellitus (DM2). To investigate the roles of hIAPP and islet amyloid in DM2, we generated transgenic mice expressing hIAPP in...

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Autores principales: Höppener, J. W. M., Jacobs, H. M., Wierup, N., Sotthewes, G., Sprong, M., de Vos, P., Berger, R., Sundler, F., Ahrén, B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386890/
https://ncbi.nlm.nih.gov/pubmed/18497871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/697035
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