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Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. T...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684849/ https://ncbi.nlm.nih.gov/pubmed/23435449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc38982k |
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