S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis()

Compelling evidence indicates that oxidative stress contributes to motor neuron injury in amyotrophic lateral sclerosis (ALS), but antioxidant therapies have not yet achieved therapeutic benefit in the clinic. The nuclear erythroid 2-related-factor 2 (Nrf2) transcription factor is a key regulator of...

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Detalhes bibliográficos
Main Authors: Mead, Richard J., Higginbottom, Adrian, Allen, Scott P., Kirby, Janine, Bennett, Ellen, Barber, Siân C., Heath, Paul R., Coluccia, Antonio, Patel, Neelam, Gardner, Iain, Brancale, Andrea, Grierson, Andrew J., Shaw, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2013
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684770/
https://ncbi.nlm.nih.gov/pubmed/23608463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.018
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