Mechanism for KRIT1 release of ICAP1-mediated integrin activation suppression

KRIT1 (Krev/Rap1 Interaction Trapped-1) mutations are observed in ~40% of autosomal dominant cerebral cavernous malformations (CCM), a disease occurring in up to 0.5% of the population. We show that KRIT1 functions as a switch for β1 integrin activation by antagonizing ICAP1 (Integrin Cytoplasmic As...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Weizhi, Draheim, Kyle M., Zhang, Rong, Calderwood, David A., Boggon, Titus J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684052/
https://ncbi.nlm.nih.gov/pubmed/23317506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.12.005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items