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Mechanism for KRIT1 release of ICAP1-mediated integrin activation suppression
KRIT1 (Krev/Rap1 Interaction Trapped-1) mutations are observed in ~40% of autosomal dominant cerebral cavernous malformations (CCM), a disease occurring in up to 0.5% of the population. We show that KRIT1 functions as a switch for β1 integrin activation by antagonizing ICAP1 (Integrin Cytoplasmic As...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684052/ https://ncbi.nlm.nih.gov/pubmed/23317506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.12.005 |
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