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The roles of 3′-exoribonucleases and the exosome in trypanosome mRNA degradation

The degradation of eukaryotic mRNAs can be initiated by deadenylation, decapping, or endonuclease cleavage. This is followed by 5′–3′ degradation by homologs of Xrn1, and/or 3′–5′ degradation by the exosome. We previously reported that, in African trypanosome Trypanosoma brucei, most mRNAs are deade...

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Detalhes bibliográficos
Main Authors: Fadda, Abeer, Färber, Valentin, Droll, Dorothea, Clayton, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683928/
https://ncbi.nlm.nih.gov/pubmed/23697549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.038430.113
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