Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

African trypanosomes are an excellent system for quantitative modelling of post-transcriptional mRNA control. Transcription is constitutive and polycistronic; individual mRNAs are excised by trans splicing and polyadenylation. We here measure mRNA decay kinetics in two life cycle stages, bloodstream...

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Publicado en:Mol Microbiol
Main Authors: Fadda, Abeer, Ryten, Mark, Droll, Dorothea, Rojas, Federico, Färber, Valentin, Haanstra, Jurgen R, Merce, Clemetine, Bakker, Barbara M, Matthews, Keith, Clayton, Christine
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285177/
https://ncbi.nlm.nih.gov/pubmed/25145465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12764
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