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The roles of 3′-exoribonucleases and the exosome in trypanosome mRNA degradation
The degradation of eukaryotic mRNAs can be initiated by deadenylation, decapping, or endonuclease cleavage. This is followed by 5′–3′ degradation by homologs of Xrn1, and/or 3′–5′ degradation by the exosome. We previously reported that, in African trypanosome Trypanosoma brucei, most mRNAs are deade...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683928/ https://ncbi.nlm.nih.gov/pubmed/23697549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.038430.113 |
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