Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination

The ability to sense metabolic stress is critical for successful cellular adaptation. In eukaryotes, the AMP-activated protein kinase (AMPK), a highly conserved serine/threonine kinase, functions as a critical metabolic sensor. AMPK is activated by the rising ADP/ATP and AMP/ATP ratios during condit...

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Autors principals: Um, Jee-Hyun, Brown, Alexandra L., Singh, Samarendra K., Chen, Yong, Gucek, Marjan, Lee, Baeck-Seung, Luckey, Megan A., Kim, Myung K., Park, Jung-Hyun, Sleckman, Barry P., Gellert, Martin, Chung, Jay H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683797/
https://ncbi.nlm.nih.gov/pubmed/23716691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307928110
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