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RNA polymerase approaches its promoter without long-range sliding along DNA

Sequence-specific DNA binding proteins must quickly bind target sequences, despite the enormously larger amount of nontarget DNA present in cells. RNA polymerases (or associated general transcription factors) are hypothesized to reach promoter sequences by facilitated diffusion (FD). In FD, a protei...

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Detalhes bibliográficos
Main Authors: Friedman, Larry J., Mumm, Jeffrey P., Gelles, Jeff
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683791/
https://ncbi.nlm.nih.gov/pubmed/23720315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300221110
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