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RNA polymerase approaches its promoter without long-range sliding along DNA

Sequence-specific DNA binding proteins must quickly bind target sequences, despite the enormously larger amount of nontarget DNA present in cells. RNA polymerases (or associated general transcription factors) are hypothesized to reach promoter sequences by facilitated diffusion (FD). In FD, a protei...

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Détails bibliographiques
Auteurs principaux: Friedman, Larry J., Mumm, Jeffrey P., Gelles, Jeff
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683791/
https://ncbi.nlm.nih.gov/pubmed/23720315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300221110
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