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BID-induced structural changes in BAK promote apoptosis
The BCL-2 family protein BAK is responsible for mitochondrial outer membrane permeabilization (MOMP), which leads to apoptosis. The BCL-2 homology (BH) 3-only protein BID activates BAK to perform this function. We report the NMR solution structure of the human BID BH3–BAK complex, which identified t...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683554/ https://ncbi.nlm.nih.gov/pubmed/23604079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2563 |
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