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BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove

BACKGROUND: BCL-2 family proteins BAK and BAX orchestrate outer mitochondrial membrane permeabilization (MOMP) during apoptosis by forming pores in the membrane to release apoptogenic factors that commits a cell to death. BAK and BAX therefore function as a ‘point of no return’ in the apoptotic casc...

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Bibliografiska uppgifter
Huvudupphovsmän: Azad, Abul, Storey, Alan
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688461/
https://ncbi.nlm.nih.gov/pubmed/23782464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-65
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