Tyrosine dephosphorylation is required for Bak activation in apoptosis

Activation of the cell-death mediator Bak commits a cell to mitochondrial apoptosis. The initial steps that govern Bak activation are poorly understood. To further clarify these pivotal events, we have investigated whether post-translational modifications of Bak impinge on its activation potential....

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Bibliografische gegevens
Hoofdauteurs: Fox, Joanna L, Ismail, Ferina, Azad, Abul, Ternette, Nicola, Leverrier, Sabrina, Edelmann, Mariola J, Kessler, Benedikt M, Leigh, Irene M, Jackson, Sarah, Storey, Alan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989102/
https://ncbi.nlm.nih.gov/pubmed/20959805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.244
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