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Concerted Multi-Pronged Attack by Calpastatin Specifically Occludes the Catalytic Cleft of Heterodimeric Calpains
The Ca(2+)-dependent cysteine proteases, calpains, regulate cell migration,1 cell death,2 insulin secretion,3 synaptic function4 and muscle homeostasis.5 Their endogenous inhibitor, calpastatin, consists of four inhibitory repeats each of which neutralizes an activated calpain with exquisite specifi...
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| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847431/ https://ncbi.nlm.nih.gov/pubmed/19020622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07353 |
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