Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination

Demyelination is one of the pathological hallmarks of multiple sclerosis (MS). To date, no therapy is available which directly potentiates endogenous remyelination. Interleukin-11 (IL-11), a member of the gp130 family of cytokines, is upregulated in MS lesions. Systemic IL-11 treatment was shown to...

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Autori principali: Maheshwari, Anurag, Janssens, Kris, Bogie, Jeroen, Van Den Haute, Chris, Struys, Tom, Lambrichts, Ivo, Baekelandt, Veerle, Stinissen, Piet, Hendriks, Jerome J. A., Slaets, Helena, Hellings, Niels
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683504/
https://ncbi.nlm.nih.gov/pubmed/23818742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/685317
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