CNS-targeted LIF Expression Improves Therapeutic Efficacy and Limits Autoimmune-mediated Demyelination in a Model of Multiple Sclerosis

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) with an inflammatory and a neurodegenerative component. The neuropoietic cytokine leukemia inhibitory factor (LIF) is expressed in MS lesions, but its effect on lesion development is far from understood. LIF is an...

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Detalhes bibliográficos
Main Authors: Slaets, Helena, Hendriks, Jerome JA, Van den Haute, Chris, Coun, Frea, Baekelandt, Veerle, Stinissen, Piet, Hellings, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862528/
https://ncbi.nlm.nih.gov/pubmed/20068552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.311
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