Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination

Demyelination is one of the pathological hallmarks of multiple sclerosis (MS). To date, no therapy is available which directly potentiates endogenous remyelination. Interleukin-11 (IL-11), a member of the gp130 family of cytokines, is upregulated in MS lesions. Systemic IL-11 treatment was shown to...

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Autors principals: Maheshwari, Anurag, Janssens, Kris, Bogie, Jeroen, Van Den Haute, Chris, Struys, Tom, Lambrichts, Ivo, Baekelandt, Veerle, Stinissen, Piet, Hendriks, Jerome J. A., Slaets, Helena, Hellings, Niels
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683504/
https://ncbi.nlm.nih.gov/pubmed/23818742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/685317
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