Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

Identifying new targeted therapies that kill tumor cells while sparing normal tissue is a major challenge of cancer research. Using a high-throughput chemical synthetic lethal screen, we sought to identify compounds that exploit the loss of the von Hippel–Lindau (VHL) tumor suppressor gene, which oc...

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Hauptverfasser: Chan, Denise A., Sutphin, Patrick D., Nguyen, Phuong, Turcotte, Sandra, Lai, Edwin W., Banh, Alice, Reynolds, Gloria E., Chi, Jen-Tsan, Wu, Jason, Solow-Cordero, David E., Bonnet, Muriel, Flanagan, Jack U., Bouley, Donna M., Graves, Edward E., Denny, William A., Hay, Michael P., Giaccia, Amato J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683134/
https://ncbi.nlm.nih.gov/pubmed/21813754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002394
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