Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig

BACKGROUND AND PURPOSE: Nasal sensory nerves play an important role in symptoms associated with rhinitis triggered by environmental stimuli. Here, we propose that TRPV1 is pivotal in nasal sensory nerve activation and assess the potential of SB-705498 as an intranasal therapy for rhinitis. EXPERIMEN...

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Detalhes bibliográficos
Main Authors: Changani, Kumar, Hotee, Sarah, Campbell, Simon, Pindoria, Kashmira, Dinnewell, Laura, Saklatvala, Paula, Thompson, Sally-Anne, Coe, Diane, Biggadike, Keith, Vitulli, Giovanni, Lines, Marion, Busza, Albert, Denyer, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682706/
https://ncbi.nlm.nih.gov/pubmed/23441756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12145
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