A Randomised Trial Evaluating the Effects of the TRPV1 Antagonist SB705498 on Pruritus Induced by Histamine, and Cowhage Challenge in Healthy Volunteers

BACKGROUND: Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of TRPV1 releases neuropeptides; the resulting neurogenic inflammation is believed to contribute to the development of...

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Main Authors: Gibson, Rachel A., Robertson, Jon, Mistry, Harshna, McCallum, Stewart, Fernando, Disala, Wyres, Melody, Yosipovitch, Gil
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105653/
https://ncbi.nlm.nih.gov/pubmed/25047038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100610
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